The Cooper Institute

Founded in 1970 by the "Father of Aerobics"
Kenneth H. Cooper MD, MPH


Key Publications

The following Cooper Institute publications are some of the most frequently cited references in the scientific literature on topics related to physical fitness, physical activity, and health.

Authorship Publication  
Benjamin L. Willis, David Leonard, Carolyn E. Barlow, Scott B. Martin, Laura F. DeFina, Madhukar H. Trivedi Association of Midlife Cardiorespiratory Fitness With Incident Depression and Cardiovascular Death After Depression in Later Life. JAMA Psychiatry. 2018 June 27;75(9):911-917. doi:10.1001/jamapsychiatry.2018.1467 Read Abstract
Defina LF, Willis BL, Radford NB, Gao A, Leonard D, Haskell WL, Weiner MF, Berry JD. The association between midlife cardiorespiratory fitness levels and later-life dementia: a cohort study. Ann Intern Med. 2013 Feb 5;158(3):162-8. PubMed ID Number: 23381040 Read Abstract
Willis BL, Gao A, Leonard D, Defina LF, Berry JD. Midlife fitness and the development of chronic conditions in later life. Arch Intern Med. 2012 Sep 24;172(17):1333-40. PubMed ID Number: 22928178 Read Abstract
Church TS, Earnest CP, Skinner JS, Blair SN. Effects of different doses of physical activity on cardiorespiratory fitness among sedentary, overweight or obese postmenopausal women with elevated blood pressure: a randomized controlled trial. JAMA. 2007 May 16;297(19):2081-91. PubMed ID Number: 17507344 Read Abstract
LaMonte MJ, Barlow CE, Jurca R, Kampert JB, Church TS, Blair SN. Cardiorespiratory fitness is inversely associated with the incidence of metabolic syndrome: a prospective study of men and women. Circulation. 2005 Jul 26;112(4):505-12. PubMed ID Number: 16009797 Read Abstract
Dunn AL, Marcus BH, Kampert JB, Garcia ME, Kohl HW, Blair SN. Comparison of lifestyle and structured interventions to increase physical activity and cardiorespiratory fitness: a randomized trial. Journal of the American Medical Assocation. 1999 Jan 27;281(4):327-34. PubMed ID Number: 9929085 Read Abstract
Blair SN, Kohl HW, Barlow CE, Paffenbarger RS, Jr., Gibbons LW, Macera CA. Changes in physical fitness and all-cause mortality: A prospective study of healthy and unhealthy men. JAMA, 273: 1093-1098, 1995. PubMed ID Number: 7707596 Read Abstract
Blair SN, Kohl HW, Paffenberger RS, Clark DG, Cooper KH, Gibbons LW. Physical fitness and all-cause mortality. A prospective study of healthy men and women. Journal of the American Medical Association. 1989 Nov 3;262(17):2395-401. PubMed ID Number: 2795824 Read Abstract

Past Studies

The Cooper Institute conducts innovative research studies that focus on health and fitness. Throughout the years we have investigated many topics including physical fitness, depression, coronary artery calcium, musculoskeletal injuries, blood pressure, inflammatory markers, vitamin supplementation, and aging.

During this time we have completed a vast array of clinical studies to showcase our research efforts. We have provided the results of some of our most recent studies below.

Study Name Description  

Activity Counseling Trial (ACT)
The Activity Counseling Trial (ACT) was a multi-center study conducted between 1995 and 1997 in part by The Cooper Institute and was sponsored by the National Heart, Lung, and Blood Institute. The purpose of ACT was to develop and evaluate ways primary care physicians could implement physical activity counseling to sedentary patients in a clinical setting in an effort to increase and maintain their physical activity and cardiorespiratory fitness. Learn More
Project ACTIVE Project ACTIVE was a study conducted at The Cooper Institute over a 24-month period between January 1994 and January 1996 and included 235 sedentary, healthy adults. This study measured the efficiency of two different types of intervention programs designed to increase physical activity and cardiorespiratory health among participants in two study groups. Learn More
Acute Leukemia Lifestyle Intervention For Everyday (ALLIFE) Project ALLIFE, was a two phase 12-month clinical trial with 114 young adult survivors of childhood acute lymphoblastic leukemia (ALL) for phase I, and 66 survivors for phase II. The purpose of phase I was to determine the cardiovascular risk of the population, through physical and laboratory measurements, questionnaires related to health and activity level, and DXA, CT and MRI scans. Learn More
Depression Outcomes Study of Exercise (DOSE) The Depression Outcomes Study of Exercise (DOSE) was a study conducted at The Cooper Institute between July 1998 and October 2001. This was a two-phase study which evaluated the effects of aerobic exercise as the only treatment for mild to moderate major depressive disorder (MDD) AND whether the amount or dose of exercise is directly related to the alleviation of depressive symptoms. This concept is known as the dose-response relationship. Learn More
The DREW Study The DREW (Dose Response to Exercise) study was proposed in response to an NHLBI Program Announcement (Physical Activity and Cardiopulmonary Health) requesting applications on a variety of issues, including physical activity dose-response studies. Our goal is to investigate the effect of different amounts of exercise training on cardiorespiratory fitness and systolic blood pressure. Learn More
Electron Beam Tomography (EBT) We evaluated coronary artery calcium (CAC) and exercise test results (cardiorespiratory fitness [CRF] and abnormal exercise tests) as predictors of coronary heart disease (CHD). We have nearly 5,000 persons with 2 electron beam tomography (EBT) scans, which allowed us to evaluate change in CAC as a predictor of incident CHD. Learn More
HealtheTech The HealtheTech study evaluated the effectiveness of HealtheTech products for weight management. Participants were randomized to the HealtheTech program, HealtheLifestyle program, or to a delayed treatment group. Learn More
The INFLAME Study The goal of the INFLAME (Inflammation and Exercise) study, was to determine the effect of exercise training on elevated (≥ 2.0 mg/L) C-reactive protein (CRP) concentrations in initially sedentary women and men. Learn More
Lifestyle Interventions for Independence in Elders (LIFE) The LIFE (Lifestyle Interventions for Independence in Elders) study was a pilot, single-blind randomized, controlled trial involving comparison of a physical activity program of moderate intensity to a successful aging program. Learn More
Lifestyle Nutrition (LNS) The Lifestyle Nutrition Study (LNS) was a study conducted from October 2001-April 2002 in which we tested a curriculum that focused on teaching adults lifestyle skills for improving the quality of their diet. Learn More
Nordic Walking Study In our Nordic Walking Study, participants were monitored and evaluated in an effort to compare oxygen consumption and energy expenditure associated with regular walking (walking without poles) and Nordic walking (walking with poles). Learn More
Omega 3 and Exercise Study This 6-month study examined the effects of omega-3 supplementation, in combination with exercise, on weight loss and body composition in men and women 30 to 60 years of age, who were overweight and not exercising regularly. Learn More
Physically Ready for Invigorating Movement Everyday (PRIME) The PRIME (Physically Ready for Invigorating Movement Everyday) study was conducted at The Cooper Institute over a two year study period between January 1998 and January 2000. This study compared the dedication or adherence of two different groups to physical activity based on two different types of lifestyle activity intervention over six months. Learn More
Treatment with Exercise Augmentation for Depression (TrEAD) TrEAD is a 4-year study funded by the National Institute of Mental Health evaluating the efficacy of aerobic exercise as an adjunctive treatment (i.e., augmentation strategy) for Major Depressive Disorder (MDD). Learn More
Vitamins and Supplements Study Because elevated C-reactive protein (CRP) levels are associated with an increased risk for cardiovascular disease and diabetes, we sought to determine whether multivitamin supplementation with Cooper Complete® reduces CRP levels in our Vitamin and Supplement Study. Learn More
The WIN Study The Women’s Injury (WIN) study was a 5-year prospective, observational study of 918 women living in the Dallas-Ft Worth area. The study monitored physical activity participation and injury incidence among study participants. Learn More