The Cooper Institute

Founded in 1970 by the "Father of Aerobics"
Kenneth H. Cooper MD, MPH



The goal of the INFLAME (Inflammation and Exercise) study, was to determine the effect of exercise training on elevated (≥ 2.0 mg/L) C-reactive protein (CRP) concentrations in initially sedentary women and men.

Participants were sedentary, healthy women and men aged 18 to 75 years with an elevated plasma CRP concentration (≥ 2.0 mg/L). We randomly assigned 170 individuals equally to a no exercise control group or to an exercise group. Exercising individuals participated in 3 or 4 training sessions each week for 4 months progressing to a total energy expenditure of 16 kcal • kg-1 • week-1 (KKW), which is an exercise dose at the upper end of current public health recommendations for physical activity. The target exercise intensity was 50-70% of baseline VO2 max.


Authorship Publication  
Thompson AM, Mikus CR, Rodarte RQ, Distefano B, Priest EL, Sinclair E, Earnest CP, Blair SN, Church TS. Inflammation and exercise (INFLAME): Study rationale, design, and methods. Science Direct, Contemporary Clinical Trials 29 (2008) 418–427 Read Abstract