The Cooper Institute

Founded in 1970 by the "Father of Aerobics"
Kenneth H. Cooper MD, MPH


ALLIFE (Acute Leukemia Lifestyle Intervention For Everyday)

The Cooper Institute was contracted by the University of Texas Southwestern Medical Center to conduct DXA and CT scans for this project. Project ALLIFE, was a two phase 12-month clinical trial with 114 young adult survivors of childhood acute lymphoblastic leukemia (ALL) for phase I, and 66 survivors for phase II. The purpose of phase I was to determine the cardiovascular risk of the population, through physical and laboratory measurements, questionnaires related to health and activity level, and DXA, CT and MRI scans.

From the 114 participants in phase I, 66 physically inactive participants were selected to continue on to phase II of the project. Physical inactivity was defined as less than 150 minutes of moderate or vigorous intensity activity per week, as measured by the 7-day physical activity recall (PAR). The 66 participants in phase II of the study were randomized to receive either the Lifestyle intervention (ALLIFE-I) or a generic health newsletter (ALLIFE-SC).

The Lifestyle intervention consisted of ongoing communication between a Health Educator and the ALLIFE-I participants, through mail, scheduled telephone calls, and the internet. The Health Educator was available to participants to answer questions, assist in setting goals, and identifying barriers to physical activity. ALLIFE-I participants also received the Active Living Everyday workbook and a subscription to the Active Living Partners website.

Participants randomized to the ALLIFE-SC group received a monthly generic wellness newsletter, the UC Berkeley Wellness Letter, by mail. They also had access to the Berkeley Wellness website. No additional counseling, other than what they received in their usual care, was provided. At the end of the 12-month study period, all participants in this group received the Active Living Every Day workbook and a subscription to the Active Living Partners website.

Major data collection occurred at baseline, 6, and 12 months. For phase II, the primary research hypothesis was that the Lifestyle intervention would significantly increase physical activity (as defined by the 7-day PAR) and cardiorespiratory fitness (as measured by the V02 max treadmill test) in adult survivors of childhood ALL as compared to standard care. All testing concluded in January 2007 and currently the ALLIFE study is in the data analysis phase.


Authorship Publication  
Janiszewski PM, Oeffinger KC, Church TS, Dunn AL, Eshelman DA, Victor RG, Brooks S, Turoff AJ, Sinclair E, Murray JC, Bashore L, Ross R. Abdominal Obesity, Liver Fat, and Muscle Composition in Survivors of Childhood Acute Lymphoblastic Leukemia The Journal of Clinical Endocrinology & Metabolism Vol. 92, No. 10 3816-3821
PubMed ID Number: 17652222
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Oeffinger KC, Adams-Huet B, Victor RG, Church TS, Snell PG, Dunn AL, Eshelman-Kent DA, Ross R, Janiszewski PM, Turoff AJ, Brooks S, Vega GL. Insulin Resistance and Risk Factors for Cardiovascular Disease in Young Adult Survivors of Childhood Acute Lymphoblastic Leukemia Journal of Clinical Oncology, Vol 27, No 22 (August 1), 2009: pp. 3698-3704
PubMed ID Number: 19564534
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