The LIFE (Lifestyle Interventions for Independence in Elders) study was a pilot, single-blind randomized, controlled trial involving comparison of a physical activity program of moderate intensity to a successful aging program.
A total of 400 sedentary persons aged 70-85 years who are at risk of disability were followed for at least one year at one of four intervention sites: Wake Forest University School of Medicine in Winston Salem, NC, the University of Pittsburgh, Pittsburgh, PA, The Cooper Institute in Dallas, TX, and the Stanford University in Palo Alto, CA. The Administrative Coordinating Center and the Data Management and Quality Control Center were at Wake Forest University School of Medicine.
This pilot study yielded the necessary preliminary data to design a definitive Phase 3 randomized, controlled trial. By providing a conclusive answer regarding whether physical activity is effective for preventing major mobility disability or death, the results of the full-scale trial will have relevant clinical and public health implications and will fill an important gap in knowledge for practicing evidence-based geriatric medicine.
|Fielding RA, Katula J, Miller ME, Abbott-Pillola K, Jordan K, Glynn NW, Goodpaster B, Walkup MP, King AC, Rejeski WJ, and for the Life Study Investigators.||Activity Adherence and Physical Function in Older Adults with Functional Limitations. Med. Sci. Sports Exerc., Vol. 39, No. 11, pp. 1997–2004, 2007|
|Pahor M, Blair SN, Espeland M, Fielding R, Gill TM, Guralnik JM, Hadley EC, King AC, Kritchevsky SB, Maraldi C, Miller ME, Newman AB, Rejeski WJ, Romashkan S, Studenski S.||Effects of a Physical Activity Intervention on Measures of Physical Performance: Results of the Lifestyle Interventions and Independence for Elders Pilot (LIFE-P) Study Journal of Gerontology: MEDICAL SCIENCES, 2006, Vol. 61A, No. 11, 1157–1165|